Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis

BRE Ansell; DB Dwyer; SJ Wood; E Bora; WJ Brewer; TM Proffitt; D Velakoulis; PD McGorry; C Pantelis

Journal article

Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis

BRE Ansell, DB Dwyer, SJ Wood, E Bora, WJ Brewer, TM Proffitt, D Velakoulis, PD McGorry, C Pantelis

Psychological Medicine | Published : 2015

DOI: 10.1017/S0033291714001652

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Abstract

Background Whether there are differential effects of first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) on the brain is currently debated. Although some studies report that FGAs reduce grey matter more than SGAs, others do not, and research to date is limited by a focus on schizophrenia spectrum disorders. To address this limitation, this study investigated the effects of medication in patients being treated for first-episode schizophrenia or affective psychoses. Method Cortical thickness was compared between 52 first-episode psychosis patients separated into diagnostic (i.e. schizophrenia or affective psychosis) and medication (i.e. FGA and SGA) subgroups. Pa..

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University of Melbourne Researchers

Brendan Ansell Author

Dom Dwyer Author

Stephen Wood Author

Dennis Velakoulis Author

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Grants

Awarded by Ian Potter Foundation

Funding Acknowledgements

This research was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (Grants 970598 and 981112) and NHMRC Program Grant (ID: 566529). Support was also provided by an NHMRC Clinical Career Developmental Award (ID: 359223) to S. Wood; an NHMRC Senior Principal Research Fellowship (ID: 628386) to C. Pantelis; National Alliance for Research on Schizophrenia and Depression (NARSAD) Distinguished Investigator Awards from the Brain and Behavior Research Foundation (USA) to C. Pantelis and P. McGorry; the Ian Potter Foundation, Melbourne; Woods Family Trust, Melbourne; and a grant from the Victorian Health Promotion Foundation, Melbourne. B. Ansell was supported by the Undergraduate Research Opportunities program (Melbourne University) and the Victorian Life Sciences Computation Initiative; and had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.